Phytochemistry Studies

Intranasal administration of the essential oil from Perillae Folium ameliorates social defeat stress-induced behavioral impairments in mice.

Researchers investigated the antidepressant mechanism of essential oil from Perillae Folium (PFEO). PFEO is commonly used in traditional Chinese medicine to treat depression. The study aims to uncover the specific mechanism behind its antidepressant effects.

Nguyen LTH et al (2024).
J Ethnopharmacol.
PubMed:
38224793

Phytochemical Analysis, acetylcholinesterase inhibition, antidiabetic and antioxidant activity of Atriplex halimus L. (Amaranthaceae Juss.).

Mediterranean saltbush contains beneficial compounds like phenols and flavonoids, which have antioxidant properties. These compounds also have potential health benefits against diabetes and acetylcholinesterase-related conditions. Enzyme activities are linked to the presence of terpenes, sterols, saponins, coumarins, and carotenoids.

Mkaddem Guedri M et al (2024).
Chem Biodivers.
PubMed:
38224199

Phytochemical Properties of Crataegus azarolus Berries Decoction Extract and Evaluation of its Protective Activity Against Acetic Acid-Induced Ulcerative Colitis in Rats.

The researchers found that the extract from berries had a protective effect against ulcerative colitis induced by acetic acid in rats. The extract showed antioxidant activity and reduced damage to the colon by stimulating mucus secretion and reducing inflammation. This suggests that the extract could be a potential treatment for ulcerative colitis.

Sammari H et al (2024).
Dose Response.
PubMed:
38223297

Creating saponin-free yellow pea seeds by CRISPR/Cas9-enabled mutagenesis on β-amyrin synthase.

Scientists use CRISPR/Cas9 to edit a gene in pea seeds, resulting in a 99.8% reduction in bitter compounds. Protein levels increase while starch decreases. Potential for improving pea cultivars using this technique is promising but more research is needed for real-world applications.

Hodgins CL et al (2024).
Plant Direct.
PubMed:
38222934

Essential Oil of Matricaria chamomilla Alleviate Psoriatic-Like Skin Inflammation by Inhibiting PI3K/Akt/mTOR and p38MAPK Signaling Pathway.

Researchers investigated the potential of German chamomile essential oil for treating skin inflammation. This study fills in the knowledge gap and offers a natural remedy option for dermatologists to consider.

Chen G et al (2024).
Clin Cosmet Investig Dermatol.
PubMed:
38222858

In silico network pharmacology study on Glycyrrhiza glabra: Analyzing the immune-boosting phytochemical properties of Siddha medicinal plant against COVID-19.

Immunosenescence and age-related immune system changes contribute to the severity of COVID-19. Glycyrrhiza glabra in a polyherbal formulation boosts immunity and has antiviral properties. Phytoconstituents, particularly liquiritigenin, inhibit the major protease protein of SARS-CoV-2, highlighting potential for clinical drug development.

Sekaran K et al (2024).
Adv Protein Chem Struct Biol.
PubMed:
38220426