Identification of Novel Alkaloids from Portulaca oleracea L. and Characterization of Their Pharmacokinetics and GLP-1 Secretion-Promoting Activity in STC-1 Cells.

Six new alkaloids found in L plant can lower blood glucose levels by stimulating the release of GLP-1, potentially offering preventive and therapeutic benefits for diabetes. One compound displayed higher GLP-1 secretion and faster absorption than existing diabetes medication nateglinide.

Su W et al (2023).

J Agric Food Chem.

DOI:

10.1021/acs.jafc.3c05191

PubMed:

38038649

Structural feature-based strategy for the identification of diterpene alkaloids in Aconitum carmichaeli Debeaux.

Researchers used LC-MS to identify 230 diterpene alkaloids in raw Aconitum carmichaelii and 466 in fermented Aconitum carmichaelii, improving identification accuracy and discovering potential new compounds.

Liu Z et al (2023).

Fitoterapia.

DOI:

10.1016/j.fitote.2023.105761

PubMed:

38036079

Identification of Potential Phytochemical Inhibitors From Conium maculatum Targeting the Epidermal Growth Factor Receptor in Metastatic Colorectal Cancer via Molecular Docking Analysis.

Scientists screened phytochemicals from a plant as potential inhibitors of EGFR in metastatic colorectal cancer (mCRC). 25 compounds had favorable drug-like properties, with 12 showing high affinity for EGFR. Seven compounds were predicted to be safe and effective, warranting further investigation and optimization.

Venkateswaran S et al (2023).

Cureus.

DOI:

10.7759/cureus.48000

PubMed:

38034159

Phytochemical analysis, antioxidant, and antimicrobial activities of Jordanian Pomegranate peels.

Pomegranate peels from Jordan contain high levels of phenolic compounds, flavonoids, and tannins. The ethanol extract shows strong antimicrobial activity and the water extract has high antioxidant activity. Pomegranate peels could be utilized for medical purposes and as a source of bioactive ingredients.

Sweidan N et al (2023).

PLoS One.

DOI:

10.1371/journal.pone.0295129

PubMed:

38032959

Cinchonine: A Versatile Pharmacological Agent Derived from Natural Cinchona Alkaloids.

Parveen S et al (2023).

Curr Top Med Chem.

DOI:

10.2174/0115680266270796231109171808

PubMed:

38031797

Targeted chemical profiling for p-HAP glycosides by using molecular networking and comparative analysis of their contents between Artemisia japonica and Artemisia capillaris.

Zhang C et al (2023).

J Asian Nat Prod Res.

DOI:

10.1080/10286020.2023.2287665

PubMed:

38031435

Evaluation of the anti-nociceptive profile of essential oil from Melissa officinalis L. (lemon balm) in acute and chronic pain models.

Scientists studied the plant Melissa officinalis and its extracts, which are used in traditional medicine to treat epilepsy and pain. Understanding its properties can help make informed decisions in the lab for potential applications in medicine.

Chindo BA et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117500

PubMed:

38030022

Gas chromatography/mass spectrometry analysis and uv absorptivity of bio-oils extracted from some locally grown plant seeds in nothern Nigeria.

Runde M et al (2023).

Heliyon.

DOI:

10.1016/j.heliyon.2023.e20872

PubMed:

38027663