Phytochemistry Studies

Non-targeted chemical analysis of consumer botanical products labeled as blue cohosh (Caulophyllum thalictroides), goldenseal (Hydrastis canadensis), or yohimbe bark (Pausinystalia yohimbe) by NMR and MS.

This study analyzed botanical dietary supplements using NMR and mass spectrometry to assess product quality and authenticity. Outliers were identified, and known constituents helped determine product authenticity. NMR and MS data provided similar and complementary results.

Quiroz-Delfi GO et al (2023).
Anal Bioanal Chem.
PubMed:
37910202

Safety and efficacy of a feed additive consisting of an essential oil obtained from the fruit of Coriandrum sativum L. (coriander oil) (FEFANA asbl).

Coriander oil approved for use as an animal feed additive; safe levels determined, no consumer/environmental concerns. Irritant to skin, eyes, and respiratory tract. Efficacy in feed not an issue.

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) et al (2023).
EFSA J.
PubMed:
37908443

Mechanism of Paris polyphylla saponin II inducing autophagic to inhibit angiogenesis of cervical cancer.

Paris polyphylla saponin II (PPII) inhibits tumor angiogenesis, but its mechanism is unknown. This study found that PPII increases autophagy in HUVEC cells through the PI3K/AKT/mTOR pathway, thereby inhibiting Hela cell proliferation, invasion, and migration. Care because PPII could potentially be used to treat cervical cancer.

Cheng H et al (2023).
Naunyn Schmiedebergs Arch Pharmacol.
PubMed:
37906274

Four new alkaloids from the roots of Dactylicapnos scandens.

Four new alkaloids were discovered, along with five existing ones, from the bulbs. The structures were determined through analysis and calculations. They were tested for their impact on neuronal Ca mobilization in neocortical neurons. Compound showed potential in inhibiting spontaneous Ca oscillations at low concentrations.

Wu Q et al (2023).
J Asian Nat Prod Res.
PubMed:
37905564