Deciphering the Anticancer Arsenal of Piper longum: Network Pharmacology and Molecular Docking Unveil Phytochemical Targets Against Lung Cancer.

Study used network pharmacology and omics to identify bioactive compounds in for potential lung cancer therapy. Key targets include CTNNB1, STAT3, HIF1A, HSP90AA1, and ERBB2. Compounds like 6-alpha-diol show promise for treatment.

Varadharajan V et al (2024).

Int J Med Sci.

DOI:

10.7150/ijms.98393

PubMed:

39113883

Optimization of saponin extraction from the leaves of Panax notoginseng and Panax quinquefolium and evaluation of their antioxidant, antihypertensive, hypoglycemic and anti-inflammatory activities.

Scientists developed an extraction process for saponins in and plants, showing antioxidant, antihypertensive, hypoglycemic, and anti-inflammatory properties. These saponins could be used in functional foods and natural products.

Liang ZW et al (2024).

Food Chem X.

DOI:

10.1016/j.fochx.2024.101642

PubMed:

39113743

Antidepressant Effect and Mechanism of Picea mariana Essential Oil on ReserpineInduced Depression Model Mice.

Picea mariana essential oil improved depression symptoms in mice by regulating neurotransmitters and proteins in the brain, potentially reducing nerve damage.

Wang Y et al (2024).

J Microbiol Biotechnol.

DOI:

10.4014/jmb.2405.05013

PubMed:

39113199

Phytochemical profiling and antioxidant evaluation of Rhododendron arboreum Sm leaf and flower: integrative analysis using advanced analytical techniques.

Kom YD, Ramaswamy K and Suresh S (2024).

Drug Dev Ind Pharm.

DOI:

10.1080/03639045.2024.2390029

PubMed:

39110842

Improvement of glucolipid metabolism and oxidative stress via modulating PI3K/Akt pathway in insulin resistance HepG2 cells by chickpea flavonoids.

Zhou K et al (2024).

Food Chem X.

DOI:

10.1016/j.fochx.2024.101630

PubMed:

39108625

The gap-free genome and multi-omics analysis of Citrus reticulata 'Chachi' reveal the dynamics of fruit flavonoid biosynthesis.

Zhu C et al (2024).

Hortic Res.

DOI:

10.1093/hr/uhae177

PubMed:

39108584

Investigation of the phytochemical profiling and antioxidant, anti-diabetic, anti-inflammatory, and MDA-MB-231 cell line antiproliferative potentials of extracts from Ephedra alata Decne.

Study on Ephedra alata Decne extracts found high antioxidant properties, phenolic and flavonoid compounds. Acetone extract showed strongest antioxidant activity, possible anti-inflammatory, anti-diabetic, and anticancer effects. Important for potential medicinal uses.

Al Jaafreh AM et al (2024).

Sci Rep.

DOI:

10.1038/s41598-024-65561-9

PubMed:

39107351

Shatavarin-IV, a steroidal saponin from Asparagus racemosus, inhibits cell cycle progression and epithelial-to-mesenchymal transition in AGS cells under hyperglycemic conditions.

A study found that Shatavarin-IV, a compound from Asparagus racemosus, effectively inhibits gastric cancer progression in hyperglycemic conditions by inducing cell cycle arrest and apoptosis, inhibiting migration and invasion, and regulating ECM turnover. This could lead to new treatments for patients with GC-diabetes co-morbidity.

Chatterjee A et al (2024).

Steroids.

DOI:

10.1016/j.steroids.2024.109487

PubMed:

39106908