Phytochemistry Studies

Alkaloids in Chelidonium majus L: a review of its phytochemistry, pharmacology and toxicology.

Researchers studied the alkaloids in L. plant, known for its medicinal properties. These alkaloids have various pharmacological effects including anti-microbial and anti-inflammatory properties. This review provides a basis for using L. in medicinal chemistry research.

Li XL et al (2024).
Front Pharmacol.
PubMed:
39239653

Amoebicidal activity of essential oils and essential oil-based microemulsions of Aloysia citrodora Ortega ex Pers., Cymbopogon winterianus Jowitt ex Bor and Ocimum gratissimum L. against Acanthamoeba polyphaga trophozoites.

Essential oils from Aloysia citrodora, Cymbopogon winterianus, and Ocimum gratissimum showed potential in killing Acanthamoeba polyphaga. Microemulsions with these oils were effective. Relevant for potential anti-amoebic treatments.

Siqueira IB et al (2024).
J Appl Microbiol.
PubMed:
39237458

Piperlongumine, a natural alkaloid from Piper longum L. ameliorates metabolic-associated fatty liver disease by antagonizing the thromboxane A(2) receptor.

TL;DR: Piperlongumine (PL) from Piper longum L. fruits improved MAFLD in mice by reducing hepatic gluconeogenesis, lipogenesis, and insulin resistance. PL targets CRTC2, CREB, and Srebp-1c, and antagonizes TP receptor to combat MAFLD induced by HFD. Potential therapeutic strategy.

Dai Y et al (2024).
Biochem Pharmacol.
PubMed:
39236933

Phytochemical composition, simulated digestive bioaccessibility and cytotoxicity of Ficus auriculata Lour. fruits: In vitro and in silico insights.

Ficus auriculata fruit extracts show high levels of antioxidants, enzyme inhibition, anti-inflammatory, and anticancer properties. Querciturone may be effective for diabetes and inflammation. Ficus auriculata fruits have potential as functional food.

Jenipher C et al (2024).
Food Chem.
PubMed:
39236381

Lignans from Sambucus williamsii Protect Bone Via Microbiome.

SWH lignans improve bone health, but levels too low to detect in rats. Likely works through gut microbiome. Research may lead to new osteoporosis treatments.

Xiao HH et al (2024).
Curr Osteoporos Rep.
PubMed:
39235563

Phenolic Compound Profiles, Antioxidant and Cytoprotective Activity of  Elaeagnus conferta Roxb. Fruit.

Three varieties of Elaeagnus conferta fruit from China were found to have high levels of antioxidants and protective effects on injured human cells. This suggests they could be useful for food industries.

Lu J et al (2024).
Chem Biodivers.
PubMed:
39235431

Antioxidant, anti-inflammatory and antibacterial activities of methanol extract and essential oil of two varieties of Citrus sinensis L. in Iran.

Study on antioxidant, anti-inflammatory, antifungal, antibacterial properties of two varieties of Iranian oranges. Northern orange skin had highest phenol and flavonoid content, antioxidant activity, anti-inflammatory effects, and positive impact on Gram-positive bacteria.

Bahramikia S, Habibi S and Shirzadi N (2024).
Nat Prod Res.
PubMed:
39234994

Grapevine varieties show different sensitivities to flavonoid alterations caused by high temperatures under two irrigation conditions.

Grapes of different varieties respond differently to heat and drought. Tempranillo is most affected while Grenache is more resilient. Understanding this helps optimize grape growth and wine quality amidst changing climate conditions.

Pascual I et al (2024).
Food Res Int.
PubMed:
39232526