Phytochemistry Studies

Comprehensive phytochemical profiling of Phyllanthus emblica L. flowers on UHPLC/MS quadrupole time of flight, HPTLC, HPLC, and NMR analytical platforms reveals functional metabolites with potent anti-inflammatory effects in human (THP-1) macrophages.

Balkrishna A et al (2024).
Phytochem Anal.
PubMed:
39160136

Synthesis, biological activities and mechanistic studies of C(20)-ketone pachysandra alkaloids as anti-hepatocellular carcinoma agents.

Researchers designed and synthesized 23 novel C-ketone pachysandra alkaloids to combat liver cancer, showing stronger anticancer activity with low toxicity. Compound 6k inhibits liver cancer cell proliferation and migration through the JAK2/STAT3 pathway, making it a promising treatment option.

Zhao J et al (2024).
Mol Divers.
PubMed:
39158620

Extraction, Phytochemical profile, and neuroprotective activity of Phyllanthus emblica fruit extract against sodium valproate-induced postnatal autism in BALB/c mice.

Study evaluated EAFA extract's effect on VPA-induced autism in mice, showing improved behavior, antioxidant activity, reduced inflammation, and neuroprotection. EAFA extract may be a potential treatment for autism.

Gouda B et al (2024).
Heliyon.
PubMed:
39157403

Assessment of the anticancer potential of certain phenolic and flavonoid components in ginger capsules using colorectal cancer cell lines coupled with quantitative analysis.

Researchers found that ginger extract had strong anticancer effects on colorectal cancer cells, with high levels of quercetin. This suggests potential for novel and more effective CRC treatments using ginger supplements.

Al Azzam KM et al (2024).
Biomed Chromatogr.
PubMed:
39152776