Phytochemistry Studies

Comprehensive Metabolite Identification of Genipin in Rats Using Ultra-High-Performance Liquid Chromatography Coupled with High Resolution Mass Spectrometry.

A study identified 50 genipin metabolites in rats, showing that these metabolites can be reabsorbed into the body. This helps understand their pharmacological effects and safety evaluations.

Cui Z et al (2023).
Molecules.
PubMed:
37687136

Direct Polyphenol Attachment on the Surfaces of Magnetite Nanoparticles, Using Vitis vinifera, Vaccinium corymbosum, or Punica granatum.

This study developed a method to synthesize magnetite nanoparticles using natural sources (grapes, blueberries, and pomegranates). These nanoparticles have a dual function, acting as reducing agents and bonding with Fe ions. They also demonstrated high heating capabilities and were found to be safe for leukemia cells.

Matías-Reyes AE et al (2023).
Nanomaterials (Basel).
PubMed:
37686958

Overview on the Polyphenol Avenanthramide in Oats (Avena sativa Linn.) as Regulators of PI3K Signaling in the Management of Neurodegenerative Diseases.

A group of compounds called Avenanthramides found in oats have antioxidant, anti-inflammatory, and anti-apoptotic properties. They can potentially modulate the PI3K signaling pathway, which is implicated in neurodegenerative diseases. More research is needed to understand how they work and their potential as a therapeutic strategy.

Wankhede NL et al (2023).
Nutrients.
PubMed:
37686782

Picrasidine J, a Dimeric β-Carboline-Type Alkaloid from Picrasma quassioides, Inhibits Metastasis of Head and Neck Squamous Cell Carcinoma.

Picrasidine J, a compound isolated from a plant, inhibits cell motility, migration, and invasion in head and neck squamous cell carcinoma (HNSCC). It also inhibits the expression of serine protease KLK-10 and phosphorylation of ERK. This suggests that picrasidine J could be a promising anticancer compound for preventing HNSCC metastasis and progression.

Ho HY et al (2023).
Int J Mol Sci.
PubMed:
37686036

Identification and Quantification of the Major Phenolic Constituents in Castanea sativa and Commercial Interspecific Hybrids (C. sativa x C. crenata) Chestnuts Using HPLC-MS/MS.

This study identified and quantified various phenolic compounds in chestnuts, including dicarboxylic acid derivatives, hydroxybenzoic acids, hydroxycinnamic acids, and flavanols. Contrary to the assumption, commercial hybrid cultivars did not have a superior metabolic profile compared to "native" accessions.

Medic A et al (2023).
Int J Mol Sci.
PubMed:
37685892

New Healthy Low-Sugar and Carotenoid-Enriched/High-Antioxidant Beverage: Study of Optimization and Physicochemical Properties.

This study looked at the effects of lutein carotenoid, extract, and essential oil as antioxidants in a low-sugar and carotenoid-enriched beverage. The results showed that these components had a synergistic effect and the beverage could potentially enhance health benefits, particularly for diabetic patients.

Fakhri LA, Ghanbarzadeh B and Falcone PM (2023).
Foods.
PubMed:
37685198