Dammarane-type triterpenoid saponins isolated from Gynostemma pentaphyllum ameliorate liver fibrosis via agonizing PP2Cα and inhibiting deposition of extracellular matrix.
New gypenosides derived from Gynostemma pentaphyllum have potential as anti-fibrotic agents for treating chronic hepatic disorders, particularly hepatic fibrosis. Compound 5 shows promise in mitigating hepatic fibrosis in mice.
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- Chin J Nat Med.
- PubMed:
- 37611978