Phytochemistry Studies

The potential of lemon balm (Melissa officinalis L.) essential oil as an anti-anxiety agent - is the citronellal the activity carrier?

The hunt for anxiolytic drugs has been challenging, leading to increased use of ethnomedicines like Melissa officinalis L. (lemon balm) for self-managing anxiety symptoms. The herb has been traditionally used for its calming effects and has shown efficacy in clinical studies. Its active principles, including rosmarinic acid and flavonoids, modulate neurotransmitter systems implicated in anxiety disorders. This highlights the potential of natural products as alternative therapies.

Stojanović NM et al (2023).
J Ethnopharmacol.
PubMed:
37207879

Multitargeted molecular docking and dynamics simulation studies of flavonoids and volatile components from the peel of Citrus sinensis L. (Osbeck) against specific tumor protein markers.

In this study, researchers investigated the potential medicinal properties of flavonoids and volatile components from the peel of (L.) Osbeck, commonly known as the sweet orange. Their findings suggest that flavonoids have a higher probability of being effective against certain anti-cancer drug targets compared to volatile components. The compound chlorogenic acid showed the strongest binding affinity to important anti-cancer targets, indicating its therapeutic potential. These results highlight the importance of flavonoids from sweet oranges and call for further research to optimize their use in medical treatments.

Rajiv Gandhi G et al (2023).
J Biomol Struct Dyn.
PubMed:
37203996