Neferine, an alkaloid, reduces prostate cell proliferation in mice with BPH. It inhibits growth and ROS production in human prostate cells, suggesting it as a potential treatment for BPH.
A study used a knowledge graph, ADInt, to predict new non-pharmaceutical interventions (NPI) for Alzheimer's Disease (AD) using computational drug repurposing. The graph included AD concepts and potential interventions, integrating dietary supplement domain knowledge graph and semantic relations. Machine learning models were compared to learn representation, and the R-GCN model outperformed others. Discovery patterns were used to generate mechanism pathways for high scoring predictions. The study discovered plausible mechanisms for photodynamic therapy and Choerospondias axillaris preventing AD. This study presents a novel methodology for discovering NPIs for AD and potentially other clinical problems.
Researchers identified challenges in understanding sweet potato storage root initiation, suggesting further investigation of hormone signaling and prioritizing candidate genes from other crops.
This study notes that patients can suffer harm from using conventional and complementary medicines together. However, this harm can be avoided. The researchers emphasize the importance of healthcare professionals educating patients about safe practices when using CMs alongside conventional medicine.