Identification of lignans as ATP citrate lyase (ACLY) inhibitors from the roots of Pouzolzia zeylanica.
- Li JL et al (2023).
- Nat Prod Res.
- PubMed:
- 37265118
In the pursuit of reducing the mortality rate of breast cancer, researchers investigated the effects of combining PL with extracts from Smilax corbularia and S. glabra (PSS) on various breast cancer cell lines. The study aimed to uncover a more effective therapeutic regimen for breast cancer treatment. By observing the effects of PSS on MCF7, T47D, MDA-MB-231, and MDA-MB-468 cell lines, the researchers hope to contribute to the development of improved treatment options for this prevalent disease.
This study identified Hemidesmus indicus as a potential source for antidiabetic medications. The herb showed high extractive yield and inhibited carbohydrate hydrolytic enzymes. Molecular modeling techniques confirmed its potential as an inhibitor of alpha-amylase and alpha-glucosidase, suggesting it could be developed as a lead for type-2 diabetes medications.
This study examined the effects of for patients with type 2 diabetes. It found that administration reduced body weight, BMI, and HbAc, but had no significant impact on arterial stiffness, endothelial dysfunction, blood pressure, glucose, and lipids.