Disease-Modifying Effects of Vincamine Supplementation in Drosophila and Human Cell Models of Parkinson's Disease Based on DJ-1 Deficiency.

Researchers found that a natural compound called vincamine showed promise in treating Parkinson's disease by improving motor ability in a fly model and reducing oxidative stress-induced death in human cells. Vincamine was shown to suppress PD-related symptoms and increased mitochondrial viability while decreasing apoptosis in human cells. The study also suggested that targeting voltage-gated sodium channels may be a promising avenue for treating PD.

Sanz FJ, Solana-Manrique C and Paricio N (2023).

ACS Chem Neurosci.

DOI:

10.1021/acschemneuro.3c00026

PubMed:

37289979

Labdane-type diterpenoids and sesquiterpenes from Curcuma aromatica and their nitric oxide inhibitory activity in lipopolysaccharide-stimulated RAW264.7 macrophages.

Hien NT et al (2023).

J Asian Nat Prod Res.

DOI:

10.1080/10286020.2023.2220273

PubMed:

37289576

In Silico Screening and Validation of Achyranthes aspera as a Potential Inhibitor of BRAF and NRAS in Controlling Thyroid Cancer.

Genetic variations in thyroid cancer, called SNPs, can help diagnose, predict outcomes, and develop personalized treatments for patients with this common endocrine tumor.

Alamri A et al (2023).

Anticancer Agents Med Chem.

DOI:

10.2174/1871520623666230607125258

PubMed:

37287303

Porcine cardiac blood - Salvia miltiorrhiza root alleviates cerebral ischemia reperfusion injury by inhibiting oxidative stress induced apoptosis through PI3K/AKT/Bcl-2/Bax signaling pathway.

The researchers investigated the potential mechanism of Salvia miltiorrhiza Bge mixed with porcine cardiac blood in preventing brain ischemia/reperfusion injury. The specific role of oxidative stress induced cell apoptosis was examined.

Zhou S et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.116698

PubMed:

37286116

Salvia mitiorrhiza Bunge aqueous extract attenuates infiltration of tumor-associated macrophages and potentiates anti-PD-L1 immunotherapy in colorectal cancer through modulating Cox2/PGE2 cascade.

Salvia miltiorrhiza Bunge, a Chinese medicinal herb known for invigorating blood circulation, has shown promising results in treating cancer. Inspired by traditional Chinese medicine, this study highlights the potential of Salvia miltiorrhiza as an effective treatment option. Its significant role in combating cancer makes it a valuable addition to the field of medicine.

Song M et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.116735

PubMed:

37286115

7β-hydroxycholesterol and 7-ketocholesterol: new oxidative stress biomarkers of sarcopenia inducing cytotoxic effects on myoblasts and myotubes.

Ghzaiel I et al (2023).

J Steroid Biochem Mol Biol.

DOI:

10.1016/j.jsbmb.2023.106345

PubMed:

37286110

Research on the improvement effect of Saposhnikovia divaricata (Trucz.) Schischk on rheumatoid arthritis based on the "component-target-pathway" association.

Liu CL et al (2023).

Anal Biochem.

DOI:

10.1016/j.ab.2023.115184

PubMed:

37285946

Hippocampal pituitary adenylate cyclase-activating polypeptide mediates rapid antidepressant-like effects of Yueju pill.

Yueju pill, a Chinese Medicine, up-regulates PACAP to activate PKA-CREB signaling and produce rapid antidepressant effects. Mice with hippocampal PACAP knockdown exhibited depression-like behavior and blunted antidepressant response. Administration of Yueju pill increased PACAP and PKA levels, and reversed depression-like behavior in chronically stressed mice. Iridoids fraction of Gardenia jasminoides was identified as an important component of Yueju pill with rapid antidepressant-like behavior through increased hippocampal PACAP expression. The study suggests that up-regulation of PACAP may represent a novel mechanism for antidepressant effects.

Ren L et al (2023).

Neuropeptides.

DOI:

10.1016/j.npep.2023.102350

PubMed:

37285664