Effects of combined cannabidiol (CBD) and hops (Humulus lupulus) terpene extract treatment on RAW 264.7 macrophage viability and inflammatory markers.
- Dammann I et al (2023).
- Nat Prod Bioprospect.
- PubMed:
- 37284961
This study investigated the impact of Stellera chamaejasme extract (SCE) on multidrug resistance in breast cancer. They used two cell lines, one sensitive to chemotherapy and one resistant. The results showed that SCE significantly inhibited the proliferation of both cell lines and reduced drug resistance. Moreover, SCE induced apoptosis in the cells, as evidenced by nuclear changes and increased apoptotic cell proportions. Additionally, SCE promoted autophagy and altered the expression of proteins related to apoptosis and cell cycle regulation. These findings suggest that SCE may be effective in combating drug resistance in breast cancer cells.