This study investigated the effects of riboceine and leaf extract on diabetic rats. The results suggest that these substances have potential as antidiabetic and antioxidant agents.
This study explored the impact of bitter leaf-flavored non-alcoholic wheat beer on insulin secretion and GLUT-2 expression in diabetic rats, potentially relevant for managing type 2 diabetes.
Scientists have discovered a potential new treatment for hepatocellular carcinoma, the most common liver tumor. They synthesized a compound called thymoquinone-oxime and tested its effects on liver cancer cells. The results showed that thymoquinone-oxime has anti-tumor properties, increasing cell death, DNA damage, and oxidative stress in a dose-dependent manner. It also decreased mitochondrial function and glutathione levels. These findings offer hope for developing new therapeutic strategies to combat this deadly form of cancer.
Licorice root extract, specifically Glycyrrhiza inflata (GI), shows promise in preventing breast cancer in high-risk postmenopausal women. This natural product has high aromatase inhibition potency, which is important for suppressing estrogen and preventing cancer growth. Phytoestrogens found in licorice, such as liquiritigenin, also inhibit aromatase and reduce uterine growth in vivo. Liquiritigenin further decreases RNA translation, protein biosynthesis, and metabolism in breast tissue, and slows down cell proliferation. These findings suggest that liquiritigenin could be an effective preventive measure for breast cancer in high-risk postmenopausal women.
Brevilin A, a natural compound, has been discovered to have anti-tumor properties in prostate cancer cells. In our study, we investigated the relationship between Brevilin A and the biological behaviors of these cells. We found that Brevilin A inhibited cell proliferation, migration, and invasion, and also promoted apoptosis. This was achieved by suppressing the expression of lncRNA H19 and E2F3, while increasing the level of miR-194. Furthermore, our experiments using a mouse model confirmed that Brevilin A had a tumor-repressing effect. Overall, Brevilin A shows promise as a potential treatment for prostate cancer.