Polyphyllin VII protects from breast cancer-induced osteolysis by suppressing osteoclastogenesis via c-Fos/NFATc1 signaling.

This study explores the potential of Polyphyllin VII (PP7), a compound derived from a traditional Chinese herb, in treating bone destruction caused by metastatic breast cancer. The researchers found that administering PP7 significantly reduced osteolysis induced by breast cancer cells in mice. PP7 also inhibited the formation of osteoclasts, reduced bone resorption, and promoted the formation of osteoblasts. The study suggests that PP7 has the potential to be a safe and effective treatment for preventing and treating bone destruction in breast cancer patients with bone metastases.

Yang Q et al (2023).

Int Immunopharmacol.

DOI:

10.1016/j.intimp.2023.110316

PubMed:

37253315

Genome-wide identification, evolution and expression profiles analysis of bHLH gene family in Castanea mollissima.

Yu L et al (2023).

Front Genet.

DOI:

10.3389/fgene.2023.1193953

PubMed:

37252667

Adaptations in the transformation of cassava (Manihot esculenta Crantz; Euphorbiaceae) for consumption in the dietary management of diabetes: the case of Palikur, or Parikwene People, from French Guiana.

Rapinski M, Cuerrier A and Davy D (2023).

Front Nutr.

DOI:

10.3389/fnut.2023.1061611

PubMed:

37252236

Andaliman (Zanthoxylum acanthopodium DC.) a herbal medicine from North Sumatera, Indonesia: Phytochemical and pharmacological review.

Adrian et al (2023).

Heliyon.

DOI:

10.1016/j.heliyon.2023.e16159

PubMed:

37251868

Green-synthesized nanoparticles of the polyherbal extract attenuate the necrosis of pancreatic β-cell in a streptozotocin-induced diabetic model.

Hasan Chowdhury MA et al (2023).

Heliyon.

DOI:

10.1016/j.heliyon.2023.e16137

PubMed:

37251822

Transcriptome-wide expression analysis of MYB gene family leads to functional characterization of flavonoid biosynthesis in fruit coloration of Ziziphus Mill.

Muhammad N et al (2023).

Front Plant Sci.

DOI:

10.3389/fpls.2023.1171288

PubMed:

37251769

Visualization and identification of benzylisoquinoline alkaloids in various nelumbo nucifera tissues.

Hao C et al (2023).

Heliyon.

DOI:

10.1016/j.heliyon.2023.e16138

PubMed:

37251486

Evaluation of antioxidant capacity, structure, and surface morphology of ginger (Zingiber officinale) using different extraction methods.

Jorge-Montalvo P, Vílchez-Perales C and Visitación-Figueroa L (2023).

Heliyon.

DOI:

10.1016/j.heliyon.2023.e16516

PubMed:

37251458