Celery (Apium graveolens L.) Exosome-like Nanovesicles as a New-Generation Chemotherapy Drug Delivery Platform against Tumor Proliferation.
Celery exosome-like nanovesicles (CELNs) have emerged as a promising option for drug delivery due to their high cellular uptake efficiency. Compared to other plant-derived nanovesicles, CELNs showed better tolerance and less toxicity as biotherapeutic roles in mice models. Encapsulating doxorubicin (DOX) into CELNs resulted in a more efficient treatment for tumors compared to conventional synthetic carriers like liposome, both in vitro and in vivo. This study highlights the potential of CELNs as a new-generation drug delivery carrier with distinct advantages.
- Lu X et al (2023).
- J Agric Food Chem.
- PubMed:
- 37222554