Origanum majorana L. protects against neuroinflammation-mediated cognitive impairment: a phyto-pharmacological study.

The study investigated the potential of using Origanum majorana L. extract to delay the onset and progression of neurodegenerative diseases such as Alzheimer's disease. Neuroinflammation and oxidative stress were found to play a critical role in the development of these diseases. The study assessed the phytochemical characteristics of the extract and its neuroprotective effects in a mouse model of neuroinflammation. The findings indicate that natural phenolics such as Origanum majorana L. may have potent antioxidant and anti-inflammatory properties that could be useful in treating neurodegenerative diseases.

Wagdy R et al (2023).

BMC Complement Med Ther.

DOI:

10.1186/s12906-023-03994-x

PubMed:

37210483

Ginger essential oil and citral ameliorates atherosclerosis in ApoE(-/-) mice by modulating trimethylamine-N-oxide and gut microbiota.

Panyod S et al (2023).

NPJ Sci Food.

DOI:

10.1038/s41538-023-00196-0

PubMed:

37210385

Inhibition of Staphylococcus aureus biofilms by poly-L-aspartic acid nanoparticles loaded with Litsea cubeba essential oil.

Lin L et al (2023).

Int J Biol Macromol.

DOI:

10.1016/j.ijbiomac.2023.124904

PubMed:

37210052

Pedunculoside inhibits epithelial-mesenchymal transition and overcomes Gefitinib-resistant non-small cell lung cancer through regulating MAPK and Nrf2 pathways.

Researchers investigated the potential of Pedunculoside (PE) in treating non-small cell lung cancer (NSCLC) and its resistance to Gefitinib, a common therapy. PE, derived from Ilex rotunda Thunb., has demonstrated anti-inflammatory, lipid-lowering, and anti-tumor effects. The study aimed to understand the therapeutic effect and underlying mechanisms of PE. This research is significant as it may provide insights into new treatment options for NSCLC and combating Gefitinib resistance.

Fan Q et al (2023).

Phytomedicine.

DOI:

10.1016/j.phymed.2023.154884

PubMed:

37209605

Neuroprotective effect of herbal extracts inhibiting soluble epoxide hydrolase (sEH) and cyclooxygenase (COX) against chemotherapy-induced cognitive impairment in mice.

Chemotherapy can cause memory and motor function deficits. This study tested the effectiveness of inhibitors of the enzyme sEH, known to reduce inflammation and improve memory, in an animal model of chemotherapy-induced cognitive impairment. The inhibitors successfully preserved cognitive function by reducing oxidative stress and inflammation in the brain. The herbal extract Mentat was also effective, and Lepidium meyenii less so. Overall, sEH inhibition shows promise in protecting against chemotherapy's adverse effects on the brain.

Kulkarni R et al (2023).

Biochem Biophys Res Commun.

DOI:

10.1016/j.bbrc.2023.05.008

PubMed:

37209564

Preparation and identification of a novel peptide with high antioxidant activity from corn gluten meal.

Yu X et al (2023).

Food Chem.

DOI:

10.1016/j.foodchem.2023.136389

PubMed:

37209437

Molecular insights into the responses of barley to yellow mosaic disease through transcriptome analysis.

Zhang M et al (2023).

BMC Plant Biol.

DOI:

10.1186/s12870-023-04276-x

PubMed:

37208619

A first insight into the genomic background of Ilex pubescens (Aquifoliaceae) by flow cytometry and genome survey sequencing.

Zhou P et al (2023).

BMC Genomics.

DOI:

10.1186/s12864-023-09359-5

PubMed:

37208610