The review article discusses the potential neuroprotective properties of phytoestrogen-isoflavones present in Trifolium pratense (Red clover) for the treatment of neurodegenerative disorders. Studies have shown that Trifolium pratense contains more than 30 isoflavone compounds, including biochanin A, daidzein, formononetin, and genistein. These compounds have been found to exhibit therapeutic efficacy against different neurodegenerative disorders through molecular interactions with estrogenic receptors, anti-inflammatory, anti-oxidative, antiapoptotic, and autophagic inducing mechanisms. The review provides detailed molecular mechanisms and experimental key findings for the clinical use of Trifolium pratense-derived isoflavones for the treatment of neurodegenerative disorders.
Black cumin seeds, specifically the compound thymoquinone (TQ), show promising potential in cancer research. TQ, found in the essential oil of Nigella sativa, has various biological effects that make it a popular topic for phytotherapy studies. Researchers are working to understand its mechanisms of action, safety, and efficacy in humans. Additionally, TQ could be a valuable tool in treating cancer, as it may help overcome resistance to chemotherapy and targeted therapies caused by mutations in the KRAS gene, which regulates cell division and growth.
L. (Polygonaceae) (PH) is a traditional Chinese medicine used to treat various diseases. It has pungent flavor, mild drug properties, and mainly affects the stomach and large intestine channels.