All Studies

Antioxidant and anticancer potential of ethyl acetate extract of bark and flower of Tecoma stans (Linn) and In Silico studies on phytoligands against Bcl 2 and VEGFR2 factors.

A study evaluated the antioxidant and anticancer properties of Tecoma stans extracts. The ethyl acetate extract contained the most valuable phytochemicals, particularly flavonoids. Purified flavonoid fractions were confirmed to be enriched. The ethyl acetate extract exhibited high antioxidant activity and dose-dependent cytotoxicity against breast cancer cells. Analysis identified 10 medicinal flavonoids, with 3,5-O-dicaffeoylquinic acid and Isorhamnetin-3-O-rutinoside showing potential interactions with Bcl 2 and VEGFR2, respectively. These findings suggest that T. stans extracts have significant medicinal potential as antioxidant and anticancer agents, pending further animal studies.

CancerImmunology Tecoma stans
Narayanan M et al (2023).
Environ Res.
DOI:
10.1016/j.envres.2023.116112
PubMed:
37182829

Design, syntheses and biological evaluation of natural product aiphanol derivatives and analogues: Discovery of potent anticancer agents.

A recent study investigated the anticancer properties of aiphanol, a natural product found in traditional Chinese medicine. The researchers discovered that aiphanol can inhibit angiogenesis and tumor growth by blocking the VEGF/VEGFRs and COX2 signaling pathways. They designed and synthesized 40 derivatives and analogues of aiphanol, and two of them, 10j and 14c, showed the strongest inhibition of tumor cell growth across various cell lines. These analogues had 80 times greater potency than the original compound. The study also revealed that the presence of a specific substrate at the 7-position of benzo 1,4-dioxane is crucial for the anticancer activity. Molecular docking experiments showed that compound 14c binds tightly to both VEGFR2 and COX2. Overall, compounds 10j and 14c hold promise as potential candidates for future development of anticancer agents.

Cancer Smilax glabra
Yao L et al (2023).
Bioorg Med Chem Lett.
DOI:
10.1016/j.bmcl.2023.129326
PubMed:
37182611

Exploring the therapeutic mechanisms of Gleditsiae Spina acting on pancreatic cancer via network pharmacology, molecular docking and molecular dynamics simulation.

The dried spines of Gleditsia sinensis Lam, known as "Gleditsiae Spina," contain various chemical components. This study used network pharmacology, molecular docking, and molecular dynamics simulations to investigate the potential of Gleditsiae Spina for treating pancreatic cancer. The study identified common targets such as AKT1, TP53, TNFα, IL6, and VEGFA. Critical pathways involved fisetin, eriodyctiol, kaempferol, and quercetin. The MD simulations showed that eriodyctiol and kaempferol had stable hydrogen bonds and high binding free energy for TP53. These findings can help explore leading compounds and potential drugs for pancreatic cancer.

Cancer Gleditsia sinensis
Duan H et al (2023).
RSC Adv.
DOI:
10.1039/d3ra01761c
PubMed:
37181515

Therapeutic effects of Crataegus monogyna inhibitors against breast cancer.

A recent study combines data mining, network pharmacology, and docking analysis to potentially revolutionize breast cancer treatment. By exploring prestigious phytochemicals, the study identifies bioactive compounds in a particular plant that may alter target genes implicated in breast cancer. Docking analysis and simulation studies support these findings. The study proposes six key compounds that contribute to breast cancer development by affecting specific proteins. This integration of network pharmacology and bioinformatics provides convincing evidence for the potential of this plant to alleviate breast cancer and paves the way for further experimental research.

Cancer Crataegus monogyna
Basavarajappa GM et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1187079
PubMed:
37180727
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