Kaempferitrin, a major compound from ethanol extract of Chenopodium ambrosioides, exerts antitumour and hepatoprotective effects in the mice model of human liver cancer xenografts.

This study explores the potential of kaempferitrin, a compound found in Chenopodium ambrosioides, to inhibit tumor growth in liver cancer xenografts in mice. Researchers seek to determine both the antitumor effect and any potential toxicity associated with this compound. Understanding the effects and safety profile of kaempferitrin could lead to new treatments for liver cancer.

Su M et al (2023).

J Pharm Pharmacol.

DOI:

10.1093/jpp/rgad046

PubMed:

37203217

Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (VIII): six new withanolides from Physalis philadelphica.

Scientists have discovered that extracts from Physalis pruinosa and P. philadelphica plants have powerful anti-proliferative effects on cells infected with human T-cell leukemia virus I (HTLV-I), which causes adult T-cell leukemia/lymphoma (ATL). Further investigation into the compounds found in these plants led to the discovery of 13 withanolides, including six newly isolated compounds. One of these compounds, withaphysacarpin, demonstrated a comparable effectiveness to the chemotherapy drug etoposide in inhibiting the growth of ATL cells. This research suggests that withanolides could be potential candidates for the treatment of ATL.

Nakano D et al (2023).

J Nat Med.

DOI:

10.1007/s11418-023-01705-x

PubMed:

37202653

Immunostimulant potential of Moringa Oleifera leaves alcoholic extract versus Oregano Essential Oil (OEO) against cyclophosphamide-induced immunosuppression in broilers chicks.

Mohamed MA et al (2023).

Trop Anim Health Prod.

DOI:

10.1007/s11250-023-03620-5

PubMed:

37202581

Echinocystic acid induces the apoptosis, and inhibits the migration and invasion of non-small cell lung cancer cells.

Echinocystic acid (EA), a natural compound found in Eclipta prostrata, has shown anticancer properties in previous studies. In this study, EA was tested on non-small cell lung cancer (NSCLC) cells. The results showed that EA inhibited the growth, migration, and invasion of NSCLC cells, as well as induced cell cycle arrest and apoptosis. Further analysis revealed that EA targeted the PI3K/Akt/mTOR pathway. Moreover, EA inhibited tumor growth and induced apoptosis in NSCLC tumor xenografts in mice. These findings suggest that EA could be a potential therapeutic option for NSCLC.

Zhu D et al (2023).

Med Oncol.

DOI:

10.1007/s12032-023-02029-2

PubMed:

37202561

Bromelain supplementation and inflammatory markers: A systematic review of clinical trials.

Researchers examined the anti-inflammatory effects of bromelain, a natural enzyme from pineapple, in adults. It may be a promising alternative to reduce side effects of current anti-inflammatory drugs.

Pereira IC et al (2023).

Clin Nutr ESPEN.

DOI:

10.1016/j.clnesp.2023.02.028

PubMed:

37202035

Polyphenolic compounds of Phyllanthus amarus Schum & Thonn. (1827) and diabetes-related activity of an aqueous extract as affected by in vitro gastrointestinal digestion.

Matou M et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.116619

PubMed:

37201665

The mechanism of action of safflower total flavonoids in the treatment of endometritis caused by incomplete abortion based on network pharmacology and 16S rDNA sequencing.

Chen Y et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.116639

PubMed:

37201664

Neocryptotanshinone ameliorates insufficient energy production in heart failure by targeting retinoid X receptor alpha.

A study explored the effects of neocryptotanshinone (NCTS) on energy metabolism to protect against heart failure after myocardial infarction (AMI) through the retinoid X receptor alpha (RXRα)/PPARα pathway. NCTS improved cardiac function and increased fatty acid oxidation and mitochondrial biogenesis.

Ma L et al (2023).

Biomed Pharmacother.

DOI:

10.1016/j.biopha.2023.114868

PubMed:

37201263