This study found that a cinnamon extract containing cinnamaldehyde has anti-cancer effects on colorectal cancer cells by inhibiting cell viability, proliferation, migration, inducing cell cycle arrest, causing mitochondrial stress, and activating apoptotic proteins.
The study investigated the neuroprotective properties of clove extract and its bioactive compounds on oxidative stress in human neuroblastoma cells. The extracts reduced reactive oxygen species, restored mitochondrial function, lowered lipid peroxidation, and displayed anti-acetylcholinesterase activity. Clove's multitarget approach may make it a potential candidate for developing Alzheimer's disease drugs as it could be a safer therapy capable of aiding multiple aspects of the disease, an area where current drugs struggle.
This study explores the harmful effects of opioids, their impact on addiction and overdose, and the involvement of the mesocorticolimbic dopaminergic circuitry. It also addresses the use of synthetic opioids in athletes and the potential for doping.
Researchers have found that quercetagitrin, a natural compound from African marigold, can inhibit tau aggregation and reduce tau phosphorylation in vitro. In vivo studies showed that oral administration of the compound restored cognitive deficits and neuron loss and prevented the formation of NFTs and tau phosphorylations in P301S-tau transgenic mice. Quercetagitrin also inhibited neuroinflammation through the inhibition of NF-κB activation. These findings suggest that quercetagitrin has potential as a therapeutic medicine for Alzheimer's disease and other tauopathies.