Angelica sinensis aboveground part polysaccharide and its metabolite 5-MT ameliorate colitis via modulating gut microbiota and TLR4/MyD88/NF-κB pathway.
- Zou YF et al (2023).
- Int J Biol Macromol.
- PubMed:
- 37148926
Vitis vinifera contains dietary stilbenoids that benefit neuronal disorders related to cognitive impairment. This study investigated the effects of vitisin A, a resveratrol tetramer derived from V. vinifera stembark, on cognitive functions. In in vitro and ex vivo experiments, vitisin A increased cell survival and restored synaptic mechanisms of learning and memory. In vivo experiments showed that vitisin A ameliorated memory function disruptions in mice and upregulated BDNF-CREB signaling in the hippocampus. Overall, vitisin A exhibits neuroprotective effects by upregulating BDNF-CREB signaling and LTP, making it a potential therapeutic agent for neurodegenerative disorders.
Researchers studied the potential of synthesized nanoscale particles made from plant extracts as a possible anti-cancer agent, offering a safer alternative to current treatments.