Hypoglycemic mechanisms of Polygonatum sibiricum polysaccharide in db/db mice via regulation of glycolysis/gluconeogenesis pathway and alteration of gut microbiota.

Chen X et al (2023).

Heliyon.

DOI:

10.1016/j.heliyon.2023.e15484

PubMed:

37128343

Modulators of diabetic neuropathy and inflammation from Saponaria officinalis: Isolation of active phytochemicals and potential mechanisms of action.

Raafat K and Al Haj M (2023).

J Tradit Complement Med.

DOI:

10.1016/j.jtcme.2023.01.001

PubMed:

37128196

Polymethoxyflavone-Enriched Fraction from Ougan (Citrus reticulata cv. Suavissima) Attenuated Diabetes and Modulated Gut Microbiota in Diabetic KK-A(y) Mice.

Chen J et al (2023).

J Agric Food Chem.

DOI:

10.1021/acs.jafc.2c08607

PubMed:

37127840

Protection of Oxygen Glucose Deprivation-Induced Human Brain Vascular Pericyte Injury: Beneficial Effects of Bellidifolin in Cellular Pyroptosis.

Pericytes help maintain brain vascular health, but their role in ischemic stroke injury is unclear. Inflammation worsens stroke damage, but this study found that an immortalized human brain pericyte cell line challenged with oxygen and glucose deprivation resulted in inflammation triggered by the NLRP3 inflammasome and pyroptosis. The protein gasdermin D (GSDMD) was involved, and a compound derived from Tibetan medicine, bellidifolin, showed promise in reducing inflammasome formation and protecting against pyroptosis. These findings offer new therapeutic avenues for stroke treatment.

An D et al (2023).

Neurochem Res.

DOI:

10.1007/s11064-023-03943-7

PubMed:

37127800

Targeting apoptotic anticancer response with natural glucosinolates from cell suspension culture of Lepidium sativum.

Ibrahim MM, Mounier MM and Bekheet SA (2023).

J Genet Eng Biotechnol.

DOI:

10.1186/s43141-023-00511-y

PubMed:

37127764

CRISPR-Cas9-based repeat depletion for the high-throughput genotyping of complex plant genomes.

Rossato M et al (2023).

Genome Res.

DOI:

10.1101/gr.277628.122

PubMed:

37127332

Toddalia asiatica extract attenuates adjuvant-induced arthritis by modulating colon Th17/Treg balance and colony homeostasis.

Qin H et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.116542

PubMed:

37127142

Artemisia annua L. (Sweet wormwood) leaf extract attenuates high-fat diet-induced testicular dysfunctions and improves spermatogenesis in obese rats.

Artemisia annua, a medicinal plant used in Egyptian medicine, shows potential in improving testicular function, although the exact mechanism is still under investigation.

El-Sawy SA et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.116528

PubMed:

37127141