Pain-causing stinging nettle toxins target TMEM233 to modulate Na(V)1.7 function.
Excelsatoxin A (ExTxA), a plant-derived toxin, interacts with sodium (Na) channels in sensory neurons. TMEM233 is an essential protein for ExTxA's effects on Na channel gating, providing insights into sensory neuron function.
- Jami S et al (2023).
- Nat Commun.
- PubMed:
- 37117223