Inhibition of STAT3 phosphorylation by colchicine regulates NLRP3 activation to alleviate sepsis-induced acute lung injury.
- Liu Y et al (2023).
- Inflammopharmacology.
- PubMed:
- 37115345
Researchers seek alternative therapies for COVID-19, exploring the potential of targeting the main protease (M) to control viral replication and prevent infections, amid concerns over vaccine effectiveness.
Prunella vulgaris shows potential in treating papillary thyroid carcinoma by reducing activity and protein levels of key targets, through the core component kaempferol. A theoretical basis is provided for future research on effective components.
Article compiles information on business intelligence (BI) from various sources. Useful for understanding and making informed decisions about BI in the lab.
Researchers used network pharmacology to study the potential protective effect of Blume against Alzheimer's disease. They identified key targets of Blume and conducted protein-protein interaction and molecular docking analyses, finding that the components 4,4'-dihydroxydiphenyl methane and protocatechuic aldehyde were most strongly associated with AD, along with five core targets including GAPDH, EP300, HSP90AB1, KDM6B, and CREBBP. Both components were found to delay paralysis and inhibit aggregation of Aβ plaques in a model, with DM upregulating the expression of KDM6B and both components upregulating HSP90AB1. These results suggest that DM and PA may be potential active components of Blume in the treatment of AD.