Cytotoxic Steroidal Saponins Containing a Rare Fructosyl from the Rhizomes of Paris polyphylla var. latifolia.
- Li TY et al (2023).
- Int J Mol Sci.
- DOI:
- 10.3390/ijms24087149
- PubMed:
- 37108310
Researchers administered Memophenol, a polyphenol compound made from French grape and North American blueberry extracts, to rats with Alzheimer's disease (AD) for 30 days. The rats had been administered AlCl and D-galactose for 60 days and showed behavioral alterations and hippocampus neuronal degeneration. Memophenol reduced behavioral alterations and hippocampus neuronal degeneration, lowered phosphorylated Tau levels and APP overexpression, and reduced beta-amyloid buildup. The compound also reduced the pro-oxidative and pro-inflammatory hippocampus changes caused by AD. These findings suggest Memophenol could be a therapeutic option for AD.