Polysaccharides from Fu brick tea ameliorate obesity by modulating gut microbiota and gut microbiota-related short chain fatty acid and amino acid metabolism.

Fu brick tea polysaccharides (FBTPSs) from fermented tea leaves reduced obesity, hyperlipidemia, inflammation, and improved gut microbiota in high-fat diet-fed rats. FBTPSs may be a promising prebiotic for obesity and dysbiosis treatment.

Zhu M et al (2023).

J Nutr Biochem.

DOI:

10.1016/j.jnutbio.2023.109356

PubMed:

37087075

Exogenous γ-aminobutyric acid (GABA) alleviates nitrogen deficiency by mediating nitrate uptake and assimilation in Andrographis paniculata seedlings.

A study on Andrographis paniculata showed that exogenous GABA improved plant growth under low nitrogen conditions. GABA increased N assimilation and protein synthesis in plants, and up-regulated the activities and expression of N metabolic enzymes. GABA also increased the accumulation of α-ketoglutarate and malate for NO assimilation. N isotopic tracing and NRTs transcription showed that GABA up-regulated NRT2.4 and NRT3.2 to increase NO uptake. Primidone, an inhibitor of GABA receptor, impeded the effects of GABA on plant growth and N accumulation. The results suggest that GABA acts as a signal to up-regulate NRTs via its receptor and promote NO assimilation to alleviate N deficiency in A. paniculata.

Huang XJ et al (2023).

Plant Physiol Biochem.

DOI:

10.1016/j.plaphy.2023.107700

PubMed:

37086691

A comprehensive review of antitumor properties of Angelica species and their antitumor-responsible constituents and the underlying molecular mechanisms involved in tumor inhibition.

Sabeel Z et al (2023).

Phytother Res.

DOI:

10.1002/ptr.7841

PubMed:

37086188

Panax quinquefolius saponin inhibits vascular smooth muscle cell calcification via activation of nuclear factor-erythroid 2-related factor 2.

Lu X et al (2023).

BMC Complement Med Ther.

DOI:

10.1186/s12906-023-03961-6

PubMed:

37085826

Genome-wide comparative analysis of the valine glutamine motif containing genes in four Ipomoea species.

Si Z et al (2023).

BMC Plant Biol.

DOI:

10.1186/s12870-023-04235-6

PubMed:

37085761

l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.

This study looked at whether adding l-theanine, a substance found in green tea that affects the brain, can help in the treatment of major depressive disorder (MDD). Researchers wanted to see if it worked and was tolerable for patients. The study's results could indicate a new approach to treating MDD.

Shamabadi A et al (2023).

J Affect Disord.

DOI:

10.1016/j.jad.2023.04.029

PubMed:

37084960

Tenacissoside G alleviated osteoarthritis through the NF-κB pathway both in vitro and in vivo.

Cui X et al (2023).

Immunol Lett.

DOI:

10.1016/j.imlet.2023.04.007

PubMed:

37084895

Comparison of the molecular mechanisms of Fuzi Lizhong Pill and Huangqin decoction in the treatment of the cold and heat syndromes of ulcerative colitis based on network pharmacology.

Hu X et al (2023).

Comput Biol Med.

DOI:

10.1016/j.compbiomed.2023.106870

PubMed:

37084637