Synthetic Cathinones and Neurotoxicity Risks: A Systematic Review.

Synthetic cathinones (SCs) are the second largest class of new psychoactive substances (NPS) monitored by the EU Early Warning System. They have similar structure to cathinone and cause various neurological events, including increased alertness, mild agitation, severe psychosis, hyperthermia, and death. A systematic literature search was conducted, and 76 studies were included in the present review, highlighting neurotoxic mechanisms and toxic effects on animals and humans. Adverse effects include encephalopathy, coma, convulsions, and hallucinogenic toxidromes, as well as excited/agitated delirium syndrome and serotonin syndrome. These findings suggest that synthetic cathinones pose a significant public health and forensic toxicology challenge.

Daziani G et al (2023).

Int J Mol Sci.

DOI:

10.3390/ijms24076230

PubMed:

37047201

Bioactive Ingredients in K. pinnata Extract and Synergistic Effects of Combined K. pinnata and Metformin Preparations on Antioxidant Activities in Diabetic and Non-Diabetic Skeletal Muscle Cells.

Ramon P et al (2023).

Int J Mol Sci.

DOI:

10.3390/ijms24076211

PubMed:

37047182

Butein Inhibits Cell Growth by Blocking the IL-6/IL-6Rα Interaction in Human Ovarian Cancer and by Regulation of the IL-6/STAT3/FoxO3a Pathway.

Butein, from flowers, inhibits IL-6 signaling and shows anti-tumor effects in ovarian cancer cells by blocking IL-6/STAT3/FoxO3a pathway. Potential therapeutic agent.

Park SA et al (2023).

Int J Mol Sci.

DOI:

10.3390/ijms24076038

PubMed:

37047012

Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives.

Morshed AKMH et al (2023).

Cancers (Basel).

DOI:

10.3390/cancers15072128

PubMed:

37046789

Melatonin-induced myeloblastosis viral oncogene homologs alleviate fresh-cut lotus root browning during storage by attenuating flavonoid biosynthesis and reactive oxygen species.

Zhang C et al (2023).

J Sci Food Agric.

DOI:

10.1002/jsfa.12619

PubMed:

37046375

Polysaccharides extracted from mulberry fruits (Morus nigra L.): antioxidant effect of ameliorating H(2)O(2)-induced liver injury in HepG2 cells.

Li X et al (2023).

BMC Complement Med Ther.

DOI:

10.1186/s12906-023-03925-w

PubMed:

37046263

Ethnobotanical knowledge on native Brazilian medicinal plants traditionally used as anthelmintic agents - A review.

Kuhn Agnes KN et al (2023).

Exp Parasitol.

DOI:

10.1016/j.exppara.2023.108531

PubMed:

37044282

Mitochondrial genome of Artemisia argyi L. suggested conserved mitochondrial protein-coding genes among genera Artemisia, Tanacetum and Chrysanthemum.

Chen H et al (2023).

Gene.

DOI:

10.1016/j.gene.2023.147427

PubMed:

37044183