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Adaptogens on Depression-Related Outcomes: A Systematic Integrative Review and Rationale of Synergism with Physical Activity.

A review of 41 studies found that adaptogens, particularly St. John's Wort and saffron, may be effective non-pharmacological strategies for depression. The studies suggest that adaptogens reduce allostatic load via the regulation of BDNF. However, there is limited research on combining adaptogens with physical exercise. The review provides support for the use of St. John's Wort and saffron in depression treatment and highlights the need for more research on the efficacy of other adaptogens and the combination of herbal extracts and resistance training.

Sánchez IA et al (2023).
Int J Environ Res Public Health.
PubMed:
37047914