Mechanism and Molecular Targets of a Water-Soluble Extract of Artemisia annua on the Treatment of Alzheimer's Disease Based on Network Pharmacology and Experimental Validation.

Oxidative stress plays a key role in Alzheimer's disease (AD), leading to cognitive dysfunction. A water-soluble extract of a traditional Chinese herbal medicine has been found to have strong anti-oxidant function and improves cognitive function in 3xTg AD mice. Using network pharmacology and experimental approaches, key genes and signaling pathways associated with oxidative stress were identified. The extract was found to have anti-oxidant/neuronal survival action against HO-induced damage, thus preventing cognitive decline and pathological changes in 3xTg mice. The findings suggest the potential of the extract as a therapy for AD.

Zhou WS et al (2023).

Am J Chin Med.

DOI:

10.1142/S0192415X23500295

PubMed:

36999542

Cytotoxic terpenes from the flowers of Inula japonica against human hepatocarcinoma cells.

Wang T et al (2023).

Chem Biodivers.

DOI:

10.1002/cbdv.202300220

PubMed:

36999317

The Zebrafish Model as a New Discovery Path for Medicinal Plants in the Treatment of Parkinson's Disease.

Medicinal herbs have emerged as a promising therapy option for Parkinson's disease (PD). Zebrafish are a potentially cost-effective and efficient animal model for studying PD due to their molecular history and bioimaging properties. A review revealed that only six plants had been investigated as potential PD treatments using zebrafish, and only two - Centella asiatica and Bacopa monnieri - showed potential anti-PD activity. The study explores these plants' mechanisms of action and suggests accessible assays for further investigation.

Modarresi Chahardehi A et al (2023).

CNS Neurol Disord Drug Targets.

DOI:

10.2174/1871527322666230330111712

PubMed:

36999188

Genome-wide identification of NHX (Na(+)/H(+) antiporter) gene family in Cucurbita L. and functional analysis of CmoNHX1 under salt stress.

Shen C et al (2023).

Front Plant Sci.

DOI:

10.3389/fpls.2023.1136810

PubMed:

36998676

Efficacy of Perilla frutescens (L.) Britton var. frutescens extract on mild knee joint pain: A randomized controlled trial.

This study tested the efficacy and safety of PE extracts for relieving knee joint pain and improving function. Results showed that PFE intake for 8 weeks was more effective than placebo without major safety concerns.

Kim N et al (2023).

Front Pharmacol.

DOI:

10.3389/fphar.2023.1114410

PubMed:

36998613

Apoptotic and antiproliferative effects of Inula viscosa L. water extract in the expression of microRnas on HCT 116 cell line: an in vitro study.

Yildirim BA et al (2023).

Int J Environ Health Res.

DOI:

10.1080/09603123.2023.2197641

PubMed:

36998228

Effect of Dietary Supplementation of Zinc Nanoparticles Prepared by Different Green Methods on Egg Production, Egg Quality, Bone Mineralization, and Antioxidant Capacity in Caged Layers.

Hassan S et al (2023).

Biol Trace Elem Res.

DOI:

10.1007/s12011-023-03640-0

PubMed:

36997774

Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases.

Sadeghi M et al (2023).

Inflammopharmacology.

DOI:

10.1007/s10787-023-01136-w

PubMed:

36997729