All Studies

Betanin mitigates scopolamine-induced cognitive impairment by restoring cholinergic function, boosting brain antioxidative status, and increasing BDNF level in the zebrafish model.

Beta vulgaris's betalains have shown potential for medicinal benefits due to their anti-inflammatory and antioxidant properties. In a study with zebrafish, betanin at 50 and 100 mg/L doses demonstrated therapeutic potential for treating cognitive deficits and brain oxidative stress induced by scopolamine, while reducing anxiety and acetylcholinesterase activity. The results suggest that betanin has neuroprotective properties.

Thawkar BS and Kaur G (2023).
Fish Physiol Biochem.
PubMed:
36991213

Neuroprotective potential of Ginkgo biloba on alteration of rat cerebellum following prenatal exposure to cyclophosphamide.

This study investigated the effects of prenatal exposure to the chemotherapeutic drug cyclophosphamide on the cerebellar tissues of rats. The researchers found that exposure caused significant decreases in the number and volume of certain cells, and histopathological evaluation confirmed these findings. They also tested the neuroprotective potential of Ginkgo biloba and found that it significantly attenuated the negative effects of the drug. These results suggest that prenatal exposure to chemotherapeutic drugs can have significant impacts on brain development, but that neuroprotective agents may offer some degree of protection.

Weli SHW and Yahyazadeh A (2023).
J Chem Neuroanat.
PubMed:
36989922

Pharmacological evaluation of the anxiolytic-like effects of an aqueous extract of the Raphanus sativus L. sprouts in mice.

Researchers studied the anxiolytic effects of an aqueous extract of Raphanus sativus sprouts (AERSS) on mice using multiple tests and found that a dosage of 30mg/kg administered directly into the abdomen produced an anxiolytic-like response. They also found that the extract had no acute toxicity and that the anxiolytic activity of the extract involves GABA/BDZs and serotonin 5-HT receptors, which may be beneficial in treating anxiety. The extract's phytochemical analysis revealed several major constituents, including sulforaphene, sulforaphane, iberin, and indol-3-carbinol.

Hernández-Sánchez LY et al (2023).
Biomed Pharmacother.
PubMed:
36989714