Amelioration of cyclophosphamide-induced DNA damage, oxidative stress, and hepato- and neurotoxicity by Piper longum extract in rats: The role of γH2AX and 8-OHdG.

A study evaluated a plant, Piper longum, for its ability to protect DNA from the harmful effects of the chemotherapy drug cyclophosphamide. The plant was tested in laboratory experiments using plasmid DNA and human blood cells. It was also tested in rats to confirm its effectiveness in preventing genomic instability, oxidative stress, and organ damage. The plant was found to protect DNA, reduce chromosome damage, prevent DNA damage, and reduce organ damage without causing toxicity. This promising finding could lead to future therapies to reduce side effects of chemotherapy.

Yadav V et al (2023).

Front Pharmacol.

DOI:

10.3389/fphar.2023.1147823

PubMed:

36969834

Efficacy and safety of TCMs with anti-inflammatory effect in patients with rheumatoid arthritis: A network meta-analysis.

This study analyzed the effectiveness and safety of Traditional Chinese Medicines (TCMs) for treating rheumatoid arthritis. TCMs have anti-inflammatory effects and are widely used in China.

Fang J et al (2023).

Front Immunol.

DOI:

10.3389/fimmu.2023.1114930

PubMed:

36969172

Genetic architecture of terpene chemistry and growth traits and the impact of inbreeding on these traits in western redcedar (Thuja plicata).

Shalev TJ et al (2023).

Evol Appl.

DOI:

10.1111/eva.13526

PubMed:

36969136

Exploring the components and mechanism of Solanum nigrum L. for colon cancer treatment based on network pharmacology and molecular docking.

Chen JF et al (2023).

Front Oncol.

DOI:

10.3389/fonc.2023.1111799

PubMed:

36969029

Molecular and histological validation of modified in ovulo nucellus culture based high-competency direct somatic embryogenesis and amplitude true-to-the-type plantlet recovery in Kinnow mandarin.

Murugan T et al (2023).

Front Plant Sci.

DOI:

10.3389/fpls.2023.1116151

PubMed:

36968388

Pan-genome and transcriptome analyses provide insights into genomic variation and differential gene expression profiles related to disease resistance and fatty acid biosynthesis in eastern black walnut (Juglans nigra).

Zhou H et al (2023).

Hortic Res.

DOI:

10.1093/hr/uhad015

PubMed:

36968185

Targeting TGF-β1/miR-21 Pathway in Keratinocytes Reveals Protective Effects of Silymarin on Imiquimod-Induced Psoriasis Mouse Model.

Henriet E et al (2022).

JID Innov.

DOI:

10.1016/j.xjidi.2022.100175

PubMed:

36968096

Antidiarrheal, antisecretory and intestinal smooth muscle relaxant effects of Platanus orientalis in mice.

Bashir D et al (2023).

Pak J Pharm Sci.

PubMed:

36967492