Comparative Transcriptome Profiling Reveals Key MicroRNAs and Regulatory Mechanisms for Aluminum Tolerance in Olive.
- Wu Y et al (2023).
- Plants (Basel).
- PubMed:
- 36903838
Researchers isolated (-)-Tetrahydroalstonine (THA) and studied its effect on protecting neurons from oxygen-glucose deprivation/re-oxygenation (OGD/R)-induced damage. They pre-treated primary cortical neurons with THA and found it increased cell viability. THA also ameliorated autophagic activity and lysosomal dysfunction, which were present at the early stage of OGD/R. Additionally, THA activated the Akt/mTOR pathway, which was suppressed after OGD/R induction. This study suggests that THA exhibits promising neuroprotective effects against OGD/R-induced neuronal injury through autophagy regulation via the Akt/mTOR pathway.