All Studies

Establishment of angiotensin-converting enzyme 2 and cluster of differentiation 147 dual target cell membrane chromatography based on SNAP-tag technology for screening anti severe acute respiratory syndrome coronavirus 2 active components.

Researchers have developed a screening system that uses dual-targeted cell membrane chromatography and liquid chromatography-mass spectroscopy to analyze receptors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This method was used to identify antiviral components in Citrus aurantium extracts, including hesperidin, neohesperidin, nobiletin, and tangeretin. In vitro experiments showed these components can inhibit virus entry into cells and interact with host-virus receptors. The study provides new insight into drug-receptor interactions and may lead to the development of new antiviral drugs.

Wang H et al (2023).
J Chromatogr A.
PubMed:
36870232