DNA release from plant tissue using focused ultrasound extraction (FUSE).
- Stettinius A et al (2023).
- Appl Plant Sci.
- DOI:
- 10.1002/aps3.11510
- PubMed:
- 36818781
Silibinin, a compound extracted from milk thistle, has traditionally been used to treat liver disease. This study evaluated the potential of silibinin as an antipsychotic drug and assessed its potential toxicity. Animal studies showed that the LD of silibinin was greater than 2,000mg/kg, indicating low toxicity. Silibinin was found to prevent and reverse symptoms of schizophrenia, including stereotypy and behavioral despair. These findings suggest that silibinin is a safe drug with significant antipsychotic activity against schizophrenia.