A review on garlic as a supplement for Alzheimer's disease: a mechanistic insight in its direct and indirect effects.

Researchers are investigating various hypotheses on the pathology of Alzheimer's disease (AD), including the Amyloid beta and Tau hypotheses. New mechanisms like immune, endocrine, and vagus pathways are also being explored. Garlic possesses antioxidant properties due to its allicin content, and its beneficial effects on AD are being examined. Garlic's components, including allicin and S-allyl cysteine, show promise in their effects on amyloid beta, oxidative stress, tau protein, gene expression, and cholinesterase enzymes. While animal studies have been positive, further research on humans is needed to fully understand garlic's exact effects on AD.

Ghazimoradi MM et al (2023).

Curr Pharm Des.

DOI:

10.2174/1381612829666230222093016

PubMed:

36809972

Natural Cycloartane Triterpenoids from Corypha utan Lamk. with Anticancer Activity towards P388 Cell Lines and their Predicted Interaction with FLT3.

Heliawati L et al (2023).

Comb Chem High Throughput Screen.

DOI:

10.2174/1386207326666230210141218

PubMed:

36809943

Decoloration and alkaloid enrichment of Dactylicapnos scandens extracts based on the use of strong anion-exchange resins in tandem with strong cation-exchange silica-based materials.

Jiang H et al (2023).

J Chromatogr B Analyt Technol Biomed Life Sci.

DOI:

10.1016/j.jchromb.2023.123637

PubMed:

36809736

Hederagenin improves Alzheimer's disease through PPARα/TFEB-mediated autophagy.

Researchers investigated the potential of hederagenin (HD) as a therapeutic agent for Alzheimer's disease. HD is a triterpene compound found in various foods with known neuroprotective effects. The study focused on HD's ability to restore autophagic flux - the coordinated degradation of pathogenic proteins - which is closely associated with AD. The experimenters found that HD increases transcription factor EB (TFEB) activity, a master regulator gene, and enhances autophagic flux. These results suggest HD could be a useful treatment for AD, but further studies are needed to confirm its effectiveness.

Xie ZS et al (2023).

Phytomedicine.

DOI:

10.1016/j.phymed.2023.154711

PubMed:

36809694

Chemical Composition, Toxicity and Repellency of Inula graveolens Essential Oils from Roots and Aerial Parts against Stored-Product Beetle Tribolium castaneum (Herbst).

Ben Mustapha M et al (2023).

Chem Biodivers.

DOI:

10.1002/cbdv.202200978

PubMed:

36808818

The effect of a standardized capsule of Aloe vera gel on the quality of life in patients with systolic heart failure: A randomized double-blind placebo-controlled clinical trial.

Sabbaghzadegan S et al (2023).

Phytother Res.

DOI:

10.1002/ptr.7775

PubMed:

36808781

The mutual regulation between DcEBF1/2 and DcEIL3-1 is involved in ethylene induced petal senescence in carnation (Dianthus caryophyllus L.).

Zhu C et al (2023).

Plant J.

DOI:

10.1111/tpj.16158

PubMed:

36808165

Transcriptomic Analysis Reveals Differentially Expressed Genes Associated with Pine Wood Nematode Resistance in Resistant Pinus thunbergii.

Wang XY et al (2023).

Tree Physiol.

DOI:

pii: tpad018. 10.1093/treephys/tpad018

PubMed:

36807984