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The effect of crocin on cholestasis-induced spatial memory impairment with respect to the expression level of TFAM and PGC-1α and activity of catalase and superoxide dismutase in the hippocampus.

Cholestasis has negative effects on brain function and memory, while crocin has been shown to be neuroprotective. This study evaluated the effect of crocin on spatial learning and memory in rats with cholestasis. Bile duct ligation was used to induce cholestasis, and crocin was administered for 30 days. The results showed that crocin partially reversed the negative effects of cholestasis on spatial memory and increased levels of important proteins in the hippocampus. Crocin may have a significant neuroprotective effect on memory impairment caused by cholestasis.

Mehrabanifar S et al (2023).
Metab Brain Dis.
PubMed:
36807082