All Studies

Protective effect of Gastrodia elata blume ameliorates simulated weightlessness-induced cognitive impairment in mice.

In a study investigating the effects of microgravity on cognitive function, Gastrodia elata Blume (GEB) was found to have a significant protective effect on memory decline. Mice receiving daily treatment with GEB and Huperzine A showed improved learning and memory, associated with changes in biochemical markers and protein expressions in the hippocampus. The study suggests that GEB may have potential uses in preventing memory decline associated with long-term spaceflight and other conditions.

Chen F et al (2023).
Life Sci Space Res (Amst).
PubMed:
36682818

Crocetin antagonizes parthanatos in ischemic stroke via inhibiting NOX2 and preserving mitochondrial hexokinase-I.

Researchers have discovered that crocetin, a natural antioxidant found in saffron, can counteract the process of programmed cell death, known as parthanatos, during an ischemic stroke. They found that crocetin reduces the production of reactive oxygen species and poly (ADP-ribose), both associated with parthanatos, at early stages of the process, and prevents the degradation of hexokinase-I, which helps maintain mitochondrial function, at later stages. The study suggests that crocetin may be a potential drug candidate for preventing and treating ischemic stroke.

Wu H et al (2023).
Cell Death Dis.
PubMed:
36681688

Zingiberene, a non-zinc-binding class I HDAC inhibitor: A novel strategy for the management of neuropathic pain.

The researchers explored the potential of a rhizome extract from Zingiber officinalis in inhibiting HDAC1 to reduce neuroinflammation. This could lead to more selective and effective treatments for neurodegenerative diseases.

Borgonetti V et al (2023).
Phytomedicine.
PubMed:
36681053