All Studies

Mangiferin: A natural bioactive immunomodulating glucosylxanthone with potential against cancer and rheumatoid arthritis.

Summary: Mangiferin from Mangifera indica has immunomodulatory effects, potential for treating rheumatoid arthritis and cancer by blocking NF-κB, regulating various pathways, activating macrophages, and having proapoptotic effects. Its precise mechanisms are still unknown.$total synthesis screened in vitro & in vivo.

ArthritisCancer Mangifera indica
Akkewar AS, Mishra KA and Sethi KK (2024).
J Biochem Mol Toxicol.
DOI:
10.1002/jbt.23765
PubMed:
38967724

Draft genome sequence of Penicillium citrinum B9, a plant growth-promoting symbiont from barley rhizosphere.

Isolated plant growth-promoting fungus from Barley rhizosphere. First draft genome assembled using single-molecule sequencing. Genome spans 31.3 Mb with 10,106 protein-encoding genes. Important for agricultural research.

Genetics Hordeum vulgare
Lau KJX et al (2024).
Microbiol Resour Announc.
DOI:
10.1128/mra.00354-24
PubMed:
38967472

Cannabidiol Alleviates Oral Mucositis by Inhibiting PI3K/Akt/NF-κB-Mediated Pyroptosis.

CBD has potential anti-cancer, anti-inflammatory, and pain-relieving properties, but more research is needed to understand its therapeutic effects on oral mucositis.

Immunology Cannabis sativa
Yang J et al (2024).
Balkan Med J.
DOI:
10.4274/balkanmedj.galenos.2024.2024-2-66
PubMed:
38966918

A telomere-to-telomere gap-free reference genome assembly of avocado provides useful resources for identifying genes related to fatty acid biosynthesis and disease resistance.

Researchers sequenced the genome of avocado, finding genes related to disease resistance and fatty acid biosynthesis. Understanding these genes can improve avocado quality and health benefits.

Genetics Persea americana
Yang T et al (2024).
Hortic Res.
DOI:
10.1093/hr/uhae119
PubMed:
38966866

Drug repositioning identifies salvinorin A and deacetylgedunin (DCG) enriched plant extracts as novel inhibitors of Mpro, RBD-ACE2 and TMPRRS2 proteins.

Researchers identified natural products, such as salvinorin A and deacetylgedunin, as potential anti-SARS-CoV-2 agents using computational methods. These compounds show promise in inhibiting viral replication and cell entry, providing a potential supplement to vaccination efforts against COVID-19.

COVID-19 Azadirachta indica
Shayo MJ et al (2024).
RSC Adv.
DOI:
10.1039/d4ra02593h
PubMed:
38966817

Comparative transcriptome provides new insights to the molecular regulation of olive trees to chilling stress.

Olive trees withstand cold due to ELIP1 increasing chlorophyll for photosynthesis. bHLH66 regulates ELIP1 expression. Understanding this may improve olive cultivation in cold areas.

Genetics Olea europaea
Wu W et al (2024).
Tree Physiol.
DOI:
10.1093/treephys/tpae075
PubMed:
38965676

Identification and characterization of the RcTCP gene family and its expression in response to abiotic stresses in castor bean.

Researchers identified and characterized the TCP family genes in castor bean, shedding light on their role in plant development and stress responses. This information is crucial for understanding and manipulating these processes in agriculture.

Genetics Ricinus communis
Li Y et al (2024).
BMC Genomics.
DOI:
10.1186/s12864-024-10347-6
PubMed:
38965476

Modulatory Effects of Lactobacillus paracasei-Fermented Turmeric on Metabolic Dysregulation and Gut Microbiota in High-Fat Diet-Induced Obesity in Mice.

Researchers studied the antiobesity effects of fermented and unfermented turmeric on obese mice. Fermented turmeric showed greater weight loss, improved metabolic parameters, and modulation of gut microbiota, suggesting it may be a promising antiobesity agent.

GastroenterologyObesity Curcuma longa
Lin WS et al (2024).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.4c01501
PubMed:
38965062
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