Chromosome-Level Genome Assembly of Herpetospermum pedunculosum (Cucurbitaceae).
- Yang Y et al (2023).
- Genome Biol Evol.
- DOI:
- 10.1093/gbe/evad005
- PubMed:
- 36652386
Researchers used computer simulations and lab tests to identify natural products that can fight against the SARS-CoV-2 virus, which causes COVID-19. They screened over 140,000 natural substances, identified 38 potential hits, and tested them in lab experiments. Five of those compounds were effective at inhibiting the virus in vitro, and three of them, known as mulberry Diels-Alder-type adducts, showed potent anti-SARS-CoV-2 activity in cells. These compounds bind to the virus in a butterfly-shaped way, as confirmed through nuclear magnetic resonance experiments.