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Anti-glutamatergic effects of three lignan compounds: arctigenin, matairesinol and trachelogenin - An ex vivo study on rat brain slices.

Arctigenin, a natural bioactive compound, was compared with matairesinol and trachelogenin in their effects on synaptic activity in rat brain slices. Arctigenin and trachelogenin were found to be more potent in inhibiting glutamate receptors and decreasing the amplitude of evoked potential early component in the rat brain than matairesinol. These results suggest that trachelogenin and arctigenin could be potential candidates for the development of neuroprotective drugs.

Koech PK et al (2023).
Planta Med.
PubMed:
36592636