Natural inhibitors for acetylcholinesterase and autophagy modulators as effective antagonists for tau and β-amyloid in Alzheimer's rat model.

A study tested the effects of extracts from Rosemary and Saffron, given individually and combined, on Alzheimer's neuroinflammation in rats. The rats were given extracts over 15 days and then tested for cognitive impairment, amyloid neuroproteins, oxidative stress, and other markers. The extracts showed significant improvement in all parameters compared to the control group and a better morphological appearance in the cortex and hippocampus. Computational analysis found the extracts may impede the activity of proteins regulating disease progression, suggesting these extracts could help treat Alzeheimer's.

Hassan M et al (2023).

Biomarkers.

DOI:

10.1080/1354750X.2022.2164617

PubMed:

36594248

Ameliorative effects of Portulaca oleracea L. (purslane) and its active constituents on nervous system disorders: A review.

The use of herbal medicines is increasing in popularity for their potential to develop effective medications with minimal harmful effects. Purslane has various applications in treating disorders such as arthritis, burns, coughs, and liver disorders, as well as shortness of breath. Research shows that purslane has qualities including neuroprotective, anti-inflammatory, and antioxidant properties. This study updated existing literature on purslane and found it has potential therapeutic effects for various nervous system disorders, including Alzheimer's disease, Parkinson's disease, depression, and anxiety. More research is needed to further support its beneficial effects on these disorders.

Jalali J and Ghasemzadeh Rahbardar M (2023).

Iran J Basic Med Sci.

DOI:

10.22038/IJBMS.2022.65764.14464

PubMed:

36594059

Green synthesis of silver nanoparticles, graphene, and silver-graphene nanocomposite using Melissa officinalis ethanolic extract: Anticancer effect on MCF-7 cell line.

Motafeghi F et al (2023).

Iran J Basic Med Sci.

DOI:

10.22038/IJBMS.2022.65503.14410

PubMed:

36594058

Draft Genomes of Frankia strains AiPa1 and AiPs1 Retrieved from Soil with Monocultures of Picea abies or Pinus sylvestris using Alnus incana as Capture Plant.

Normand P et al (2023).

J Genomics.

DOI:

10.7150/jgen.77880

PubMed:

36594039

Antidepressive-Like Effect of Aegle marmelos Leaf Extract in Chronic Unpredictable Mild Stress-Induced Depression-Like Behaviour in Rats.

Researchers tested an herbal medication, standardized hydroethanolic extract of Citrus aurantium leaves, for its ability to treat depression in male rats experiencing chronic stress. The extract has been shown to have several beneficial effects on the central nervous system. The study aimed to understand the antidepressant activity of the extract, as few effective antidepressant medications without side effects exist. This study found that the extract was effective in improving depressive symptoms in rats under chronic stress. This suggests that the extract may be a promising candidate for further study as a potential antidepressant medication.

Sharma A et al (2022).

Biomed Res Int.

DOI:

10.1155/2022/6479953

PubMed:

36593774

Complete genome sequence of Stellaria aquatica virus B, a novel polerovirus that infects Stellaria aquatica.

Gudeta WF et al (2023).

Arch Virol.

DOI:

10.1007/s00705-022-05687-1

PubMed:

36593330

Hyperforin Suppresses Oncogenic Kinases and Induces Apoptosis in Colorectal Cancer Cells.

Hsu LC et al (2023).

In Vivo.

DOI:

10.21873/invivo.13067

PubMed:

36593022

Genome wide analysis of BREVIS RADIX gene family from wheat (Triticum aestivum): A conserved gene family differentially regulated by hormones and abiotic stresses.

Tiwari S et al (2023).

Int J Biol Macromol.

DOI:

10.1016/j.ijbiomac.2022.12.300

PubMed:

36592856