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Antidepressant-like effects of geniposide in chronic unpredictable mild stress-induced mice by regulating the circ_0008405/miR-25-3p/Gata2 and Oip5os1/miR-25-3p/Gata2 networks.

Geniposide (GP) is a compound found in Gardenia jasminoides Ellis that has been found to have anti-depressive activities. Researchers investigated the anti-depressive mechanism of GP in mice with depression-like behaviors induced by chronic unpredictable mild stress (CUMS). GP administration was found to reduce depression-like behaviors in CUMS mice, with transcriptome sequencing identifying Gata2 as a target. GP was found to regulate the circ_0008405/miR-25-3p/Gata2 and Oip5os1/miR-25-3p/Gata2 crosstalk networks, which could lead to potential antidepressant-like effects on CUMS mice.

Zhao Y et al (2023).
Phytother Res.
PubMed:
36515407