Analysis of the Amine Submetabolome Using Novel Isotope-Coded Pyrylium Salt Derivatization and LC-MS: Herbs and Cancer Tissues as Cases.

Liu L et al (2022).

Anal Chem.

DOI:

10.1021/acs.analchem.2c04246

PubMed:

36473140

Chromosome-scale Amaranthus tricolor genome provides insights into the evolution of the genus Amaranthus and the mechanism of betalain biosynthesis.

Wang H et al (2023).

DNA Res.

DOI:

10.1093/dnares/dsac050

PubMed:

36473054

Investigating the anti-tumoral effect of yarrow (Achillea milllefolium) on the mice in which ehrlich solid tumor is created.

Bağcı Uzun G et al (2022).

Med Oncol.

DOI:

10.1007/s12032-022-01917-3

PubMed:

36472705

[A new sesquiterpene from stems of Buddleja lindleyana].

Chen ZC, Cai YS and Yu SS (2022).

Zhongguo Zhong Yao Za Zhi.

DOI:

10.19540/j.cnki.cjcmm.20220412.203

PubMed:

36471970

[Chloroplast genome structure characteristics and phylogenetic analysis of Artemisia indica].

Lan ZH et al (2022).

Zhongguo Zhong Yao Za Zhi.

DOI:

10.19540/j.cnki.cjcmm.20220713.101

PubMed:

36471930

Alkaloid fraction of Mirabilis jalapa Linn. flowers has low cytotoxicity and increases iron absorption through Erythropoietin-Matriptase-2-Hepcidin pathway in iron deficiency Hepatocarcinoma cell model.

Suselo YH et al (2023).

Saudi J Biol Sci.

DOI:

10.1016/j.sjbs.2022.103508

PubMed:

36471797

Cannabidiol reveals a disruptive strategy for 21st century epilepsy drug discovery.

This article discusses the historical relevance of the approval of cannabidiol (CBD) for epilepsy treatment. Unlike its related compound, marijuana's Δ9-tetrahydrocannabinol, CBD does not have any euphorigenic or withdrawal effects at anticonvulsant doses. CBD also has anti-inflammatory properties. Though CBD's anticonvulsant properties were suggested in a few studies in rodent seizure models, social and regulatory pressures kept it from being clinically implemented. However, CBD was approved for the orphan disease Dravet syndrome in 2018 after its efficacy was established in randomized, placebo-controlled trials in children. The article suggests that CBD's approval is a key driver of a new discovery strategy for epilepsy treatment in the 21st century.

Del Pozo A and Barker-Haliski M (2023).

Exp Neurol.

DOI:

10.1016/j.expneurol.2022.114288

PubMed:

36471511

Evolution and functional analysis of the GRAS family genes in six Rosaceae species.

Bai Y et al (2022).

BMC Plant Biol.

DOI:

10.1186/s12870-022-03925-x

PubMed:

36471247