Phenotypically abnormal cotyledonary Vitis vinifera embryos differ in anatomy, endogenous hormone levels and transcriptome profiles.
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In a study, Gypenoside LXXV (GP-75), a natural plant compound, was administered to mice with Alzheimer's disease and diabetes. GP-75 improved cognitive function, glucose control, and insulin sensitivity in the mice. It also reduced beta-amyloid buildup in the brain and increased glucose uptake. The treatment worked by activating certain signaling pathways in the brain. These findings suggest that GP-75 has potential for treating cognitive impairment in humans with Alzheimer's and diabetes.