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The Mediterranean plant Sumac has been found to have beneficial properties, including neuroprotection and antioxidant effects. Researchers investigated its potential neuroprotective action in Parkinson's disease (PD) by studying its effects on mitochondrial functionality. They found that Sumac extract reduced reactive oxygen species (ROS) levels, but the effect on ATP levels varied depending on the individual's genetic mutations. Sumac was also found to polarize macrophages towards an M2 phenotype, which could suggest it as a potential nutraceutical approach to PD.