Untargeted metabolomics of fermented onion (Allium cepa L) using UHPLC Q-TOF MS/MS reveals anti-obesity metabolites and in vivo efficacy in Caenorhabditis elegans.

Barathikannan K et al (2023).

Food Chem.

DOI:

10.1016/j.foodchem.2022.134710

PubMed:

36323042

Genome-wide identification of RUB activating enzyme and conjugating enzyme gene families and their expression analysis under abiotic stresses in Capsicum annuum.

Wei M et al (2023).

Protoplasma.

DOI:

10.1007/s00709-022-01816-4

PubMed:

36322293

Neuroprotective effects of a new triterpenoid from edible mushroom on oxidative stress and apoptosis through the BDNF/TrkB/ERK/CREB and Nrf2 signaling pathway in vitro and in vivo.

Researchers identified 10 secondary metabolites from the edible mushroom Fr. Pilat, including a new lanostane triterpenoid. The neuroprotective function of all steroidal metabolites was investigated, and results showed that 2α-HI exhibited the most significant neuroprotective activity. The Nrf2 and BDNF/TrkB/ERK/CREB signaling pathway mediated the neuroprotective effects of 2α-HI against oxidative stress and apoptosis. The neuroprotection of 2α-HI was also verified in zebrafish. These findings suggest that Fr. Pilat could be a potential dietary supplement to ameliorate neurodegenerative diseases.

Kou RW et al (2022).

Food Funct.

DOI:

10.1039/d2fo02854a

PubMed:

36321740

In vitro acetylcholinesterase, tyrosinase inhibitory potentials of secondary metabolites from Euphorbia schimperiana and Euphorbia balsamifera.

Aljubiri SM et al (2022).

Z Naturforsch C J Biosci.

DOI:

10.1515/znc-2021-0178

PubMed:

36321624

The Determination of Molecular and Toxicological Mechanisms of Cucurbitacine E in Model Organism Drosophila melanogaster and Various Cancer Cell Lines: Molecular modelling, docking and dynamic simulation studies.

Tunçbilek AŞ, Azarkan SY and Ercan FS (2022).

Curr Comput Aided Drug Des.

DOI:

10.2174/1573409919666221031112223

PubMed:

36321227

An ethyl acetate fraction of flavonoids from Polygonum hydropiper L. exhibits an anti-inflammatory activity in PCV2-infected porcine alveolar macrophages via PI3K/Akt and NF-κB pathways.

Ren CZ et al (2022).

Vet Res Forum.

DOI:

10.30466/vrf.2021.137675.3070

PubMed:

36320309

Homeopathic Eupatorium perfoliatum in the Treatment of COVID-19.

Tomassone D et al (2023).

Homeopathy.

DOI:

10.1055/s-0042-1755363

PubMed:

36318968

Phytochemical analysis of Pithecellobium dulce (Roxb) Benth Bark via UPLC-ESI-MS/MS and evaluation of its biological activity.

Saeed Kotb S et al (2022).

Nat Prod Res.

DOI:

10.1080/14786419.2022.2140153

PubMed:

36318868