Analysis of Antioxidant Constituents from Ilex rotunda and Evaluation of Their Blood-Brain Barrier Permeability.

A study investigated the antioxidant composition of Thunb., a plant commonly used for medicinal purposes. Twig extracts showed the best potential for antioxidant capacity, and the -butanol fraction had the highest antioxidant effect. Eight marker compounds were isolated, and their structures determined. One compound (4,5-dicaffeoylquinic acid) showed significant antioxidant activity and penetrated the blood-brain barrier. This compound could be used as a potential therapeutic candidate for central nervous system drug discovery.

Kim CK et al (2022).

Antioxidants (Basel).

DOI:

10.3390/antiox11101989

PubMed:

36290712

Charged Gold Nanoparticles Promote In Vitro Proliferation in Nardostachys jatamansi by Differentially Regulating Chlorophyll Content, Hormone Concentration, and Antioxidant Activity.

Joshi S et al (2022).

Antioxidants (Basel).

DOI:

10.3390/antiox11101962

PubMed:

36290684

Antioxidant and Immune Stimulating Effects of Allium hookeri Extracts in the RAW 264.7 Cells and Immune-Depressed C57BL/6 Mice.

Jeong UY et al (2022).

Antioxidants (Basel).

DOI:

10.3390/antiox11101927

PubMed:

36290655

Phytochemical Composition and Biological Activities of Arctium minus (Hill) Bernh.: A Potential Candidate as Antioxidant, Enzyme Inhibitor, and Cytotoxic Agent.

İlgün S et al (2022).

Antioxidants (Basel).

DOI:

10.3390/antiox11101852

PubMed:

36290576

Comparative Evaluation of Various Extraction Techniques for Secondary Metabolites from Bombax ceiba L. Flowering Plants along with In Vitro Anti-Diabetic Performance.

Yasien S et al (2022).

Bioengineering (Basel).

DOI:

10.3390/bioengineering9100486

PubMed:

36290454

Anthocyanins from Opuntia ficus-indica Modulate Gut Microbiota Composition and Improve Short-Chain Fatty Acid Production.

Zhang Y et al (2022).

Biology (Basel).

DOI:

10.3390/biology11101505

PubMed:

36290409

Screening and evaluation of cytotoxicity and antiviral effects of secondary metabolites from water extracts of Bersama abyssinica against SARS-CoV-2 Delta.

Researchers conducted a study to test the antiviral capabilities of bioactive compounds found in the widely-used African herb, Bersama abyssinica, against the Delta variant of the SARS-CoV-2 coronavirus. Although the plant is used in Tanzania to treat respiratory conditions, it has not been scientifically tested for its antiviral properties. The study aimed to determine the cytotoxicity and antiviral effects of the plant's extract against the coronavirus. The results of the study could lead to a better understanding of the potential use of the herb in treating COVID-19 and respiratory infections.

Zekeya N et al (2022).

BMC Complement Med Ther.

DOI:

10.1186/s12906-022-03754-3

PubMed:

36289484

Communiferulins, farnesylated coumarins from the roots of Ferula communis and their anti-neuroinflammatory activity.

Four compounds were isolated from Ferula communis roots and characterized using spectroscopic analysis and NMR data calculation. Three new farnesylated coumarins and a farnesylated chromone were identified, and their structures were determined. The compounds were found to have inhibitory activities on IL-1β production from stimulated microglial cells.

Yoshino Y et al (2023).

J Nat Med.

DOI:

10.1007/s11418-022-01657-8

PubMed:

36289185