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A 47-year-old male with chronic kidney disease and B Cell Lymphoma successfully recovered from COVID-19 using a poly-herbal ayurvedic formulation and integrated approach while in home quarantine. The patient had recently finished chemotherapy, making treatment challenging; however, he tolerated the intervention and recovered symptomatically without respiratory complications. Ayurvedic herbs have demonstrated anti-viral and immunomodulatory effects in in vitro studies, and this case supports their potential efficacy in real-world patients when combined with Ayurvedic epistemology. Early diagnosis by RT-PCR and early use of Ayurvedic interventions may be essential for successful recovery.