Study on Components with Neuroinflammation Inhibitory Activities from Croton tiglium L. var. xiaopadou.

Researchers found a new compound, along with 33 others, in the stems of a plant called Croton tiglium L. var. xiaopadou. They tested the compounds on microglia, a type of cell in the brain related to inflammation, and found that 13 of the compounds reduced inflammation. Four of the compounds, specifically 10, 16, 18, and 21, were particularly effective and had a similar effect as a positive control drug called minocycline. These findings suggest that these compounds could potentially be used to treat brain inflammation in the future.

Zhang Y et al (2022).

Chem Biodivers.

DOI:

10.1002/cbdv.202200473

PubMed:

35931661

HPLC-MS/MS analysis of primary alkaloids in rat plasma after oral administration of "Nux vomica - Glycyrrhiza glabra decoction": A pharmacokinetic study.

Guo Y et al (2022).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2022.115588

PubMed:

35931305

Mechanisms of pancreatic tumor suppression mediated by Xiang-lian pill: An integrated in silico exploration and experimental validation.

Jiao J et al (2022).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2022.115586

PubMed:

35931303

Comparative analysis of chloroplast genomes of three medicinal Carpesium species: Genome structures and phylogenetic relationships.

Shi X et al (2022).

PLoS One.

DOI:

10.1371/journal.pone.0272563

PubMed:

35930571

On the effect of flavonoids and dietary fibre in lingonberries on atherosclerotic plaques, lipid profiles and gut microbiota composition in Apoe(-/-) mice.

Liu J et al (2022).

Int J Food Sci Nutr.

DOI:

10.1080/09637486.2022.2106358

PubMed:

35930435

Molecular dynamics and docking studies on potentially active natural phytochemicals for targeting SARS-CoV-2 main protease.

Researchers discovered that three compounds, Aegelinosides B, Epicatechin, and Feruloyltyramine, from popular herbs are potential candidates for fighting SARS-CoV-2. These compounds were screened from 87 phytochemicals and identified based on their binding energy and structural stability through molecular dynamics analysis. Comparing to popular reference compounds, Aegelinosides B demonstrated the best result. Further drug-likeness and toxicity tests also support the effectiveness of these compounds. These findings may have implications for developing treatments against COVID-19.

Karakkadparambil Sankaran S and Nair AS (2022).

J Biomol Struct Dyn.

DOI:

10.1080/07391102.2022.2107573

PubMed:

35930306

An Update on the Potential Application of Herbal Medicine in Promoting Angiogenesis.

Li J et al (2022).

Front Pharmacol.

DOI:

10.3389/fphar.2022.928817

PubMed:

35928282

Penta-O-Galloyl-β-D-Glucose in Pistacia integerrima Targets AMPK-ULK1 and ERK/STAT3 Signaling Axes to Induce ROS-Independent Autophagic Cell Death in Human Lung Cancer Cells.

Balkrishna A et al (2022).

Front Pharmacol.

DOI:

10.3389/fphar.2022.889335

PubMed:

35928273